Anthropic

Frontier LLM-based agents can overcome the ontology curation bottleneck for natural phenotypes

Linking free-text phenotype descriptions to ontology terms, typically referred to as phenotype annotation, is essential for the cross-study integration of comparative morphological data. This labor intensive process has heavily relied on highly trained human experts, which makes it challenging to scale and thus a key bottleneck. Dahdul et al. (2018) established a Gold Standard (GS) of Entity-Quality (EQ) annotations across seven phylogenetic studies and used it to evaluate three human curators and the Semantic CharaParser NLP tool with ontology-based semantic similarity metrics; they reported that machine-human consistency was significantly lower than inter-curator (human-human) consistency. Here we revisit that benchmark with five frontier hosted LLMs from Anthropic and OpenAI, each operating as an "agentic curator" within a self-contained workspace that supplies the source publication PDF, the same annotation guide used by the original human curators, the four project ontologies (UBERON, PATO, BSPO, GO), and a validation script. Evaluated against the same Gold Standard, every agent fell within the range of inter-curator variability of the three trained human biocurators of the original study; the best performing agents approached but did not reach the best performing human curator. Agents substantially outperformed Semantic CharaParser on all four metrics.

Persona Conditioning of Brand Recommendations in Retrieval-Augmented Commercial Chat: A Prominence-Stratified Cross-Provider Audit

The same prompt -- "best CRM software" -- reaches AI assistants from buyers in widely different contexts: a solo founder, an enterprise VP, a UK SMB owner. We audit how strongly that contextual variation reshapes which brands the model recommends. The audit samples 2,000 runs over a design space of 10 personas x 8 prompts x 3 model configurations x N=10 reps, with the two OpenAI cells at full 8-prompt coverage and the Anthropic sonnet-4.6 / low cell at 4-prompt coverage. Prefixing the user message with a persona drops the recommendation-set similarity (Jaccard) by Delta = -0.12 to -0.20 relative to a same-persona baseline (clustered 95% CIs exclude zero on all three measured cells; the sonnet cell's CI rests on only 4 prompt clusters and is correspondingly wider). The effect is sharply prominence-stratified: category leaders are persona-resistant (~80% same-brand consistency across personas), but mid-market brands swap up to 75% of the recommendation set as the persona changes. The Anthropic model shows a larger point-estimate effect than the OpenAI configurations, though clustered CIs overlap for the closer contrast (sonnet vs. OpenAI/high); the asymmetry is consistent with Anthropic's more retrieval-unattributed generation route (43-52% recommendations without observed retrieval-layer evidence, vs OpenAI's 8-29%, documented in Jack 2026). Any measurement of AI brand perception must condition on the buyer persona supplying the query: the same prompt produces materially different recommendation sets depending on who the model thinks is asking, and a measurement protocol that aggregates across personas systematically obscures that variation. The effect concentrates at mid-market and is largest on the most priors-reliant generation route in our audit, consistent with persona responsiveness growing as models lean more on training-data priors and richer context integration.

First head-to-head comparison of agentic AI applied to the analysis of simulated data of the Einstein Telescope

We report a comparison of two state-of-the-art agentic AI systems, Claude Code (Anthropic) and Codex (OpenAI), tasked with autonomously executing a simple end-to-end gravitational wave data analysis pipeline on a shared computing infrastructure without human intervention. The pipeline comprises power spectral density estimation from raw Einstein Telescope simulated noise, geometric template bank generation, matched filter recovery of 100 binary black hole signal injections, automated results generation, and large language model-assisted production of a manuscript formatted in the style of Physical Review D. Both agents received identical written specifications and identical compute resources. The experiment was run twice: a first run with unrealistically loud injections, and a second run with signals rescaled to a physically motivated SNR range. The scientific results converged in both runs. However, the agents exhibited substantially different behaviors and computational costs: Claude Code completed the pipeline in ~3.4 minutes with silent deviations from the specification, while Codex required ~16 minutes across explicit self-correcting restarts, including an unsolicited performance optimization of the matched filter inner loop. The autonomously generated manuscripts also diverged in length, details, and quality. In the second run, a subtle difference in the interpretation of the SNR range instruction led to a genuine scientific divergence: Claude Code silently reinterpreted the instructions, while Codex followed the specification literally. We discuss the implications of these behavioral differences, such as speed versus auditability, silent versus transparent error handling, instruction interpretation, and the criticality of intermediate data representations in multi-model pipelines, for the deployment of agentic AI in scientific computing workflows.

BODHI: Precise OS Kernel Specification Inference

The formal verification of operating system kernels requires precise specifications that capture the intended behavior of system calls. Writing these specifications manually demands deep domain expertise, motivating the use of large language models (LLMs) to automate the process. However, in OSV-Bench, a benchmark of 245 specification generation tasks derived from the Hyperkernel OS kernel, the best reported Pass@1 is 55.10%. We propose a domain knowledge prompting method (BODHI), which augments the standard few-shot prompt with a structured C-to-Python translation guide covering 15 categories of domain-specific translation patterns. Inspired by Structured Chain-of-Thought (SCoT) prompting, the guide organizes translation by separation of concerns, addressing pre-condition extraction and post-condition generation as distinct categories. Evaluated on nine models from six providers (Anthropic, Mistral, Amazon, DeepSeek, Meta, Alibaba), covering dense, mixture-of-experts and reasoning architectures, BODHI improves every model tested, with gains ranging from +11% to +32%. The best configuration (Claude Opus 4.6 + BODHI) reaches 96.73% Pass@1. BODHI reduces both syntax and semantic errors, with the strongest effect on models that have sufficient instruction-following capability to utilize structured reference material. These results demonstrate that domain knowledge injection is a model-agnostic technique that substantially bridges the gap between general-purpose code generation and formal specification synthesis.

How Well Do Models Follow Their Constitutions?

Frontier AI developers now train models against long written behavioral specifications, such as Anthropic's constitution (Anthropic, 2025a) and OpenAI's Model Spec (OpenAI, 2025a), integrated into post-training via methods like character training (Anthropic, 2024) and deliberative alignment (Guan et al., 2024). These documents serve a governance function, but it is unclear how well models actually follow them under adversarial, multi-turn pressure similar to what they would face in real-world deployment. We propose a multi-method audit pipeline that treats each lab's published specification as an auditable target: it decomposes the specification into atomic testable tenets (205 for Anthropic, 197 for OpenAI), generates multi-turn adversarial scenarios with the Petri auditing agent (Anthropic, 2025b), runs a modified SURF-style rubric search (Murray et al., 2026) to catch shallow single-turn failures Petri misses, validates flagged transcripts against the relevant specification, and compares the findings against the lab's own published system card. Applying the pipeline across seven models per specification, we find that models follow their own lab's specification substantially better with each generation. On Anthropic's constitution, the Claude family falls from a 15.0% violation rate (Sonnet 4) to 2.0% (Sonnet 4.6); on OpenAI's Model Spec, the GPT family falls from 11.7% (GPT-4o) to 3.6% (GPT-5.2 medium reasoning), with the severity ceiling falling from 10/10 to 7/10. We cannot externally isolate whether these gains come from specification-specific training, broader post-training improvements, or evaluation awareness. Remaining failures cluster around operator-imposed personas under AI-identity questioning, irreversible action in agentic deployments, and fabricated quantitative claims with false precision.

Authority Signals in Claude AI Health Citations: A Descriptive Analysis Using the Authority Signals Framework

This study seeks to determine the authority signals used by Anthropic's Claude AI in its presentation of sources when answering consumer health questions. While there exists a great deal of discourse around the quality of health citations that LLMs produce, there is limited information on the integrity of the sources the citations originate from, and to what extent the sources are, from what health professionals would consider, credible sources. This descriptive cross-sectional study used data from HealthSearchQA, which contains 3,172 consumer health questions curated by Google Research. After exclusions, a final dataset of 3,075 questions yielding 10,038 citations was analyzed. The Authority Signals Framework (Jacques et al., 2026) was applied to examine 10 authority signals across four domains for a disproportionate stratified sample of 542 sources. Established institutional sources accounted for 97.8% of all citations (n = 9,818). Medical Institutions were the most frequently cited organization type (36.5%), followed by Government Resources (31.6%) and Professional Associations (28.4%). Commercial Health Information comprised 2.2% (n = 220). The top 10 organizations accounted for 57.8% of all citations, with Mayo Clinic alone representing 24.7%. Among commercial sources in the focused sample, 86.4% displayed medical review statements, 82.5% used schema markup, and 71.8% had comprehensive content, while traditional institutional sources appeared in Claude's citations with or without these same markers. As Anthropic positions Claude for HIPAA-ready healthcare applications, these findings establish a baseline for Claude's citation behavior and demonstrate the utility of the Authority Signals Framework as a tool for ongoing, cross-platform evaluation of AI-mediated health information.